Congratulations to Dr. Hani Kuttab, first author, and Dr. Michael A. Ward, senior author, on their recent publication in Critical Care Medicine, the official journal of the Society of Critical Care Medicine (SCCM). Despite significant improvements in care, mortality from sepsis remains high. Numerous studies support the administration of early, aggressive fluid resuscitation; however, the topic remains controversial. Data on fluid resuscitation in septic patients who are perceived to be “at risk” of volume overload remains inconclusive. The objectives of this study include as follows:
1) identify predictors of reaching a 30 mL/kg crystalloid bolus within 3 hours of sepsis onset (30by3)
2) assess the impact of 30by3 and fluid dosing on clinical outcomes
3) examine differences in perceived “at-risk” volume-sensitive populations, including end-stage renal disease, heart failure, obesity, advanced age, or with documentation of volume “overload” by bedside examination
'Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock'
Critical Care Medicine: August 7, 2019